Unfortunately, 10_3 and 10_12 did not show the anti-tumor effects of the parental PD-L1_1 when tested on CT26 cancer cells due to unexpected loss of their binding ability to these cells (see Fig. 4), likely caused by mutations occurred in the affinity maturation process (Cembrola et al., Rapid affinity maturation of novel anti-PD-L1 antibodies by a fast drop of the antigen concentration and FACS selection of yeast libraries, submitted for publication, 2019). This evidence concerns the gene CD274 and cancer.