ESR2 and neoplasm: The efficacy of the combinatorial approach was then further tested on co-cultures of SK-BR-3 or JMTI-1 tumor cells with hPBMCs to exploit also the effector functions of Erb-hcAb (ADCC mediated by Fc) and the inhibitory effects of PD-L1_1 mAb in the interaction of PD-1/PD-L121,38.