Moreover Atezolizumab is currently in Phase IIA clinical trial assessing the safety and efficacy in combination with paclitaxel, Trastuzumab, and Pertuzumab in 50 patients with locally advanced, unresectable, or metastatic HER2-overexpressing breast cancer (ClinicalTrials.gov Identifier:NCT03125928). Here, ERBB2 is linked to breast carcinoma.