This question deserves attention because PrPC is cleaved by members of the disintegrin and matrix-metalloprotease family of enzymes that are upregulated in the aqueous humor (AH) of glaucomatous eyes27,28, and is likely to confound the pathogenesis and therapeutic management of POAG through cross-talk with other pathways29. The gene discussed is PRNP; the disease is open-angle glaucoma.