Autosomal-dominant forms of Fuchs’ dystrophy have been attributed to genetic variation in TCF4 (transcription factor 4)38, a novel UACR-associated locus identified here (index rs11659764, p = 2.8 × 10−11; r2 = 0.21, D' = −0.97 with rs613872, a previously reported Fuchs index SNP39). Here, TCF4 is linked to Fuchs endothelial corneal dystrophy.