At first, we constructed a Her2-specific CAR in lentiviral vector with specific cytotoxicity to Her2+ human ovarian cancer SKOV3 cells (Supplementary Fig. 1), and its combination with one of sh-PD-1, sh-Tim-3, sh-Lag-3, or scramble shRNA (Supplementary Fig. 2a). The gene discussed is ERBB2; the disease is ovarian carcinoma.