However, given that the observed gene alterations were likely confounded by deletion of other proximal genes with C11orf46 at WAGR locus, we switched in our next set of experiments to neuron-like (neuroblastoma) NSC34 Tet-On cells expressing C11orf46 shRNA to further examine C11orf46-regulated genes. This evidence concerns the gene ARL14EP and neuroblastoma.