As shown in Fig. 3a, the transcription of Tnfα, Cxcl1, Ccl2, and Ccl20 was upregulated in Spont-PyMT tumors, like in Trans-PyMT ones (Supplementary Fig. 2a), even though the fold increases were not always similar in the two tumor types. This evidence concerns the gene CXCL1 and neoplasm.