The alleviating effects of FGF21 on oxidative stress, endothelial dysfunction and reduced activations of AMPKα and ACC were substantially abrogated by the selective CaMKK2 antagonist (STO-609)36,37 in aorta or HUVEC (Figs. 6b–g, S6A–C). The gene discussed is CAMKK2; the disease is endothelial dysfunction.