To validate the potential pathophysiological significance of miR-30c induction in the therapeutic response of BrCa to ADR, we next examined the effect of miR-30c on FANCF and REV1 expression and chemosensitivity in nude mice bearing human MCF-7 and MDA-MB-231 xenografts, using cholesterol-conjugated miR-30c mimics (miR-30c agomir) or ADR (Fig. 3e). The gene discussed is FANCF; the disease is invasive breast carcinoma.