TAC1 and hepatoblastoma: Administration of SP/neurokinin-1 receptor agonist aprepitant in three human hepatoblastoma cell lines, i.e. HepT1, HepG2 and HuH6 was associated with decrease in cellular proliferation along with inhibition of Wnt pathway suggesting that activation of Wnt pathway is regulated by SP/neurokinin-1 signaling pathway [53].