YAP1 and hepatoblastoma: In hepatoblastoma cell lines (HuH6, HepG2, HepT1, HC-AFW1, HepG2 and HC-AFW1) and in Yap1-β-catenin mice model, knockout of YAP-1 or β-catenin using short interfering RNAs (siRNAs) was shown to suppress cellular proliferation and tumorigenesis, respectively.