In Yap1-β-catenin mice model, treatment with rapamycin (mammalian target of rapamycin (mTOR) inhibitor) was shown to attenuate the tumor growth over a period of time along with inhibition of mTORC1 suggesting that mTCOR1 is a potential target in YAP-1-β-catenin signaling cascade in hepatoblastoma [38]. This evidence concerns the gene YAP1 and hepatoblastoma.