Apolipoprotein E (APOE) allelles ε2 and ε4 are independent risk factors for lobar ICH, consistent with their known associations with amyloid biology.S58 APOE allelic variation is also a risk factor for CKD progression that is independent of established CKD risk factors such as diabetes and hypertension.S59. The gene discussed is APOE; the disease is Hypertension.