Similar to previous reports in the B16-F10 model [23], we found that MEDI9197 increases median survival observed with anti-PD-L1 mAb in the B16-OVA model from 29 to 34.5 days (Fig. 6e) and resulted in 2 out of 10 tumors regressing without regrowth for 59 days post tumor cell implantation, so we extended these findings to a human co-culture in vitro assay. The gene discussed is CD274; the disease is neoplasm.