Of note, a review of seven cancer lines in the publicly available University of California, Santa Cruz, genome browser database indicates CRYβB2P1 is active (marked with active histone mark, H3K4me3) and rich in transcription factor and chromatin regulatory marks, while not many regulatory marks are present for CRYβB2. These data strongly suggest CRYβB2P1 ncRNA may act in cis at the CRYβB2 locus and/or function in trans genome-wide. This evidence concerns the gene CRYBB2 and cancer.