Additionally, CCND2 expression was also correlated with JAK2 expression in two independent CRC cohorts obtained from the R2 database (https://hgserver1.amc.nl/cgi-bin/r2/main.cgi), with coefficient r values of 0.25 and 0.23 in GSE41258 and GSE37892, respectively, and statistical significance at P < 0.001 (Fig. 4f). Here, JAK2 is linked to colorectal carcinoma.