Higher Hb transfusion thresholds were reported in patients with acute coronary syndrome (ACS), septic shock, acute brain injury, those receiving extracorporeal membrane oxygenation (ECMO), with acute respiratory distress syndrome (ARDS), age over 65 years and with prolonged weaning (p < 0.001 for all patient populations, see Fig. 1). This evidence concerns the gene GSTM1 and brain injury.