Specifically, the late-differentiated CMV-specific T effector like phenotype (CD57-high, KLRG-1-high and 2B4-high, Fig. 4d) also seen in the majority of the neoantigen-specific T cells from atezolizumab responders may be associated with senescent cells with highly cytotoxic and strong anti-tumor activity [36]. This evidence concerns the gene KLRG1 and neoplasm.