They produce numerous bioactive factors such as adipokines which play roles of cytokines in metabolic disorders including obesity and related diseases, and since two decades visfatin, leptin, hepcidin, adiponectin, vaspin, apelin, chemerin, omentin, and others have been discovered and extensive studied [21–24]. This evidence concerns the gene RARRES2 and obesity due to melanocortin 4 receptor deficiency.