Combining CAI with IDO1/AhR inhibitors could lead to a more selective anti-tumor immunoreaction, which was confirmed in a specialized coculture system consisting of B16 melanoma cells expressing ovalbumin (OVA) antigen (B16-OVA) and OVA-specific CTLs derived from OT-1 transgenic mice. The gene discussed is IDO1; the disease is melanoma.