MYC and neoplasm: In addition to the role of c-Myc in tumour glycolysis, another significant transcription factor, HIF1α, could regulate the expression of key glycolytic enzymes involved in the reaction to hypoxia, such as hexokinase 2 (HK2), aldolase A, pyruvate kinase M, lactate dehydrogenase isoform A (LDHA) and phosphoglycerate kinase 1 [24–28], while the detailed mechanism is still unclear.