FUBP1 can form a complex with the distal far upstream element (FUSE) site regulating gene expression [15], including c-Myc, p21, Usp29, etc. [16, 17], which displays a broad spectrum of activities, such as promoting proliferation, cell cycle, invasion and metastasis of tumour cells [18–20]. The gene discussed is MYC; the disease is neoplasm.