In the WHO 2010 classification, gastroenteropancreatic NEN was divided into the following 3 grades based on mitotic count and Ki-67 index: NET grade 1 (NET G1) with mitotic count < 2/2 mm2 and/or Ki-67 index ≤2%, NET G2 with mitotic count 2 to 20/2 mm2 and/or Ki-67 index 3 to 20% and NEC with mitotic count > 20/2 mm2 and/or Ki-67 index > 20% [9]. The gene discussed is MKI67; the disease is neuroendocrine carcinoma.