Of note, somatic mutations in Keap1 (e.g. G333C, G350S, L413R, D236H) and the methylation of the Keap1 promoter are frequently observed in lung cancer whereas Nrf2 mutations (e.g. W24C, E82D, D77V) happen more often in esophageal cancer, which have been reviewed recently [83]. The gene discussed is NFE2L2; the disease is lung carcinoma.