IRS1 and colorectal carcinoma: miR-7-5p is more of a tumor suppressor that represses oncogenic proteins such as EGFR, IGF1R, IRS-1, IRS-2, RAF1, PIK3CD, mTOR, and PI3K, in various cancers including PDAC, liver, breast, non-small cell lung carcinoma (NSCLC), colorectal (CRC) and ovarian [42].