Russel et al. and Badoual et al. observed increased CD8+ T cell infiltration in the intraepithelial compartment in HPV+ HNSCC [35,39], whereas when investigating laryngeal, oral, hypo- and oropharyngeal tumor samples, Balermpas et al. did not find significant differences between HPV+ and HPV− SCC [42]. This evidence concerns the gene CD8A and head and neck squamous cell carcinoma.