On the other hand, sulfatase 2 (SULF2), an enzyme with 6-O-desulfatase activity on HS proteoglycans, is upregulated in HCC cells leading to enhanced release of the heparin-binding growth factors such as FGF and HGF attached to the HS sidechains of GPC3 [44,45], which in turn activates the signaling pathways mediated by their specific receptors [44,45,46,47]. The gene discussed is SULF2; the disease is hepatocellular carcinoma.