In a meta-analysis combining data from 10 studies, H. pylori seropositivity showed no overall association with pancreatic risk; however, seropositivity for CagA-positive H. pylori was associated with a reduced pancreatic cancer risk (OR = 0.78, 95% CI: 0.67–0.91), while seropositivity for CagA-negative H. pylori was associated with an increased pancreatic cancer risk (OR = 1.30, 95% CI: 1.02–1.65) [81]. Here, S100A8 is linked to pancreatic neoplasm.