Furthermore, a genome-wide association study showed significant associations between the risk of developing NASH and a specific single-nucleotide polymorphisms (SNPs) in the NNMT gene (rs694539) [61]: in this case, subjects with the AA genotype showed a statistically significant increased NASH risk, while the GG genotype seemed to be protective. The gene discussed is NNMT; the disease is metabolic dysfunction-associated steatohepatitis.