ADAR and colorectal carcinoma: In addition, miRNAs biogenesis is regulated not only by core processing enzymes, but also by many regulatory factors, such as ADAR1/B1 (adenosine deaminase, RNA specific/B1) [20], BRCA1/2 (breast cancer genes 1/2), SMADs [21], LIN28A/B (Lin-28 homolog A/B) [22] or wild type and mutant TP53 [23] that are commonly deregulated in various cancers, including colorectal cancer (CRC).