We also found that the protein expression of the cyclin b1/CDC2 kinase complex was regulated by TC7 in the two PCa cells used, thereby suggesting that TC7 arrested the cell cycle at G2/M by regulating the p38/cyclin b1/CDC2 and p53-dependent GADD45A/PLK1 signaling pathways. The gene discussed is PLK1; the disease is posterior cortical atrophy.