MAPK3 and posterior cortical atrophy: In summary, TC7 induced apoptosis of PCa cells through the regulation of key apoptotic proteins such as p53, ERK1, BAX, p38, BCL-2, caspase-8, cleaved caspase-8, and PARP1 as well as influencing the phosphorylation of ERK1 and p38 in the p38/p53/caspase 8 signaling pathway.