Our results indicate that TC7 inhibited ERK1 phosphorylation and protein expression in both the two types of PCa cells used, thus, p38-mediated regulation on the expression and phosphorylation of ERK1 might be associated with TC7-induced cell apoptosis, providing new insights in the regulation of the ERK cascade and on the consequent development of new chemotherapeutic agents against PCa with a tanshinone chemical structure. This evidence concerns the gene MAPK3 and posterior cortical atrophy.