Up to now, only a few disease models related to the Keap1–Nrf2 PPI have been evaluated in lab and clinical research, such as mouse renal inflammation [88,89], Huntington’s disease [90], drug-induced liver injury [84,91], and many cancer models [92,93,94,95,96,97,98]. The gene discussed is KEAP1; the disease is juvenile Huntington disease.