When SNCA aggregates in the brain (forming oligomers and insoluble fibrils with increased ß-sheet configuration, Lewy bodies and non-Amyloid β component) it can result in a subset of neurodegenerative disorders like Alzheimer’s disease (AD), Parkinson’s disease (PD), dementia with Lewy bodies (DLB), and other synucleinopathies [6,7]. This evidence concerns the gene SNCA and Alzheimer disease.