CFTR and cancer: The protocol here presented considers two PNAs, a PNA targeting miR-221-3p (R8-PNA-a221) and causing activation of apoptosis of treated cancer cells through inhibition of miR-221-3p functions, and a PNA targeting miR-145-5p (R8-PNA-a145), able to induce in increase of the expression of CFTR through inhibition of the CFTR regulator: miR-145-5p.