BDNF and obesity due to melanocortin 4 receptor deficiency: Since we had seen trends for decreased Bdnf gene expression in both obesity and age-related inguinal scWAT neuropathy (Fig 2G, S2B Fig), and an increase in BDNF protein secretion in response to noradrenergic stimulation (Fig 7C), we decided to investigate whether there were sex differences in BDNF expression in inguinal scWAT that may underlie the resistance to neuropathy in the diabetic female mice.