In univariable analyses, the model included the following variables: age greater than 60 years, sex, WHO subtype, hemoglobin less than 10 g/dL, platelets less than 100 × 109/L, mast cell infiltration in BM histology greater than 30%, serum tryptase greater than 150 μg/L, albumin less than 35 g/dL, alkaline phosphatase greater than the upper normal limit (UNL), and splenomegaly (palpable or radiographic, yes or no). The gene discussed is ALB; the disease is Splenomegaly.