In conclusion, it is shown that the phenotypic and neuroimaging expression in NKX6‐2 mutations can range from a complex, neonatal onset at the severe end and a childhood onset at the milder end of the spectrum and that phenotypes with epilepsy in the absence of overt hypomyelination, and diffuse hypomyelination without seizures, can occur. This evidence concerns the gene NKX6-2 and epilepsy.