Dectin‐1 is a CLR expressed primarily on myeloid cells, such as macrophages and DCs, and on a small subset of lymphocytes.5, 6 Among the complex multilayers of fungal cell walls, O‐linked mannosylated proteins and mannans in the thin outermost layer are recognized by TLRs, whereas β‐glucan molecules, the most abundant layer of the fungal cell wall, are primarily recognized by Dectin‐1 and Dectin‐2 receptors.7 Innate immune responses to fungal infection are orchestrated by the cooperative recognition of pathogen‐associated molecular patterns (PAMPs) on the fungal cell wall via TLRs and CLRs. This evidence concerns the gene CLEC7A and fungal infectious disease.