DCLK3 and infection: It is worth noting that in a true pathophysiologic context, TLR and CLR receptors are simultaneously engaged by innate immune cells; nevertheless, deficiencies in Dectin molecules alone can lead to increased infection susceptibility, demonstrating that these pathways are not entirely redundant.19, 21, 22 Furthermore, we think that the study presented here demonstrates an interesting evolutionary convergence between TLR and CLR innate immune signaling pathways, whereby acute glycolysis induction is a requirement for proper downstream effector functions mediated by both families of receptors.