Compared with those in the highest tertile, patients in the low or middle tertiles of the PCSK9 GRS (Figure 2 and eTable 10 in the Supplement) and of genetically estimated PCSK9 expression levels (Figure 2 and eTable 11 in the Supplement) had a similar risk of sepsis, cardiovascular failure, and in-hospital mortality, except that the middle tertile of genetically estimated PCSK9 expression had a higher risk of cardiovascular failure at a nominal level of significance (OR, 1.26; 95% CI, 1.01-1.58; P = .04). This evidence concerns the gene PCSK9 and Sepsis.