Mice with a deletion of Pcsk9 had decreased production of interleukin-6 and other inflammatory cytokines compared with control animals after they received intraperitoneal LPS; they also had attenuated physiological responses to LPS with greater preservation of mean arterial pressure and ejection fraction.4 In another murine model of sepsis, Pcsk9 overexpression was associated with increased bacterial dissemination, inflammation, and histopathological damage compared with control animals, whereas mice with deletion of Pcsk9 were protected against these effects.40 Here, PCSK9 is linked to Sepsis.