PCSK9 and Sepsis: None of the 4 functional PCSK9 gene variants were significantly associated with sepsis, cardiovascular failure, or in-hospital death (Figure 2 and eTable 9 in the Supplement) with or without adjustment for (1) age and sex or (2) age, sex, and comorbidities (in model adjusted for age, sex, and comorbidities, odds ratios for any loss-of function variant were 0.96 [95% CI, 0.88-1.04] for sepsis, 1.05 [95% CI, 0.90-1.22] for cardiovascular failure, and 0.89 [95% CI, 0.72-1.11] for death) (eTable 9 in the Supplement).