PCSK9 and Sepsis: Third, we used 3 genetic approaches: the 4-SNP approach that previously found an association with sepsis outcomes,4 a PCSK9 GRS previously associated with cardiovascular outcomes,30 and genetically estimated gene expression levels.19 In BioVU, rs11591147 and rs505151 and the PCSK9 GRS were significantly associated with measured LDL-C; however, estimated PCSK9 expression was not (eTables 6-8 in the Supplement).