A total of 61 502 patients met the definition of infection, of whom 10 922 white adults (5294 women [48.5%] and 5628 men [51.5%]; mean [SD] age, 60.1 [15.7] years) had genotypes available for the PCSK9 functional variants (Table 1); of these, 3391 developed sepsis, 835 developed cardiovascular failure, and 366 died during hospitalization. The gene discussed is PCSK9; the disease is infection.