KLK3 and neoplasm: The following variables were significantly associated with pathologic disease upgrading to at least GG3 disease on univariate analysis: confirmatory biopsy pathologic findings, PSA level more than 10 ng/mL, percent free PSA level less than 10%, PSA density of at least 0.15 ng/mL/mL, and a percentage of tumor involvement at least 50% of biopsy core (eTable 2 in the Supplement).