In UM tumours, the IGF‐1R/PI3K/Akt pathway is constitutively activated,28 and the elevated phosphorylation levels of Akt are related to poor prognosis in most UM.29, 30 Thus, the IGF‐1R/PI3K/Akt pathway has been regarded as a main target, which is being evaluated as a treatment to further illustrate the importance of targeting activated signalling pathways in different metastatic diseases. The gene discussed is AKT1; the disease is neoplasm.