Pristimerin (PRI), a quinonemethide triterpenoid compound, has been widely used as antioxidant, antimalarial, anti‐inflammatory and insecticidal agent.11 In recent years, PRI has been shown to inhibit the growth in several cancer cells.12, 13, 14, 15 However, the inhibitory effects of PRI on human UM cancer cells and its inhibitory potential in IGF‐1 and IGF‐1R‐mediated tumourigenesis have not yet been investigated. Here, IGF1R is linked to cancer.