IGF1 and cancer: Autophosphorylation and tyrosine kinase activity of IGF‐1R receptors play a crucial role in their signalling functions.23Therefore, the improved activity of tyrosine kinases was associated with many cancers and other proliferative diseases.24 The signalling pathways and tyrosine kinases in which they participate have thus been identified as promising targets for drug design.24, 25 In the present study, PRI could significantly reduce the proliferation and the IGF‐1R tyrosine phosphorylation induced by IGF‐1 in UM cells.