IGF1R and melanoma: Hence, this result was consistent with the finding that treatment of melanoma with selected signalling kinase inhibitors can effectively decrease proliferation and increase expression of cell cycle inhibitors.33 According to the aforementioned molecular docking suggestions, PRI was a potent inhibitor of IGF‐1R, which is consistent with previous reports that compounds with good binding affinity to the IGF‐1R tyrosine kinase have potent activity in the inhibition of cell growth.20 All these results confirm the fact that PRI inhibits IGF‐1R and its downstream signalling pathways.