Next, we applied our approach to cisplatin–vinorelbine treated lung squamous cell carcinoma (TCGA-LUSC) patients (Supplementary Table 4) and identified a set of six molecular pathways (GSEA NES = 1.67, p-value < 0.001) (Supplementary Fig. 8b) including neuroactive ligand-receptor interaction, SLC-mediated transmembrane transport, transport of mature mRNA derived from an intron-containing transcript, cytokine-cytokine receptor interaction, DNA repair, and translation pathways and their corresponding read-out genes (Supplementary Table 6). Here, CCL21 is linked to squamous cell lung carcinoma.