In addition, four TNBC markers (AGR2, HID1, MLPH, STMN1) we found regulated in EVs were also in agreement with the trends reported by Tyanova at al. We were intrigued that, other than these six markers, no additional overlapping trends were found with the rest of their 19-signature proteins, hinting at selective packaging of tumor proteins into EV cargo and in line with our in vitro data on whole-cell proteomes. This evidence concerns the gene AGR2 and neoplasm.