However, when we extracted the EV signature proteins intensities from the whole-cell lysate proteomes for hierarchical clustering (67/73 of the HER2-specific markers and 47/64 of the TNBC-specific markers identified in the whole-cell lysates) we could observe segregation into the classical breast cancer subtypes (Supplementary Fig. 6C). The gene discussed is ERBB2; the disease is breast cancer.