Both reported a good response with substantial improvement of UPDRS-III scores and reduction of LEDD postoperatively, and only slight to moderate decline in cognitive function after one and 3 years, respectively, in line with overall STN-DBS results in PD.50,51 A third case report describe a patient with a mosaicism of SNCA duplication show an overall good outcome of DBS, where GPi was chosen as target due to prominent dyskinesias and mild cognitive impairment.15 This evidence concerns the gene GPI and Cognitive impairment.