IL15 and B-cell chronic lymphocytic leukemia: This suggests that the cooperation of CpG ODNs and recombinant human IL-15 may boost the response of B-CLL through TLR9 signaling and the survival of carboxyfluorescein diacetate succinimidyl ester-labeled B-CLL cells with approaches that have yielded important insights concerning clonal growth and the activation-induced death of normal human B cells (109–111).