Dysregulation of ALP is implicated in the pathogenesis of diseases, including Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, etc. For example, various Alzheimer’s disease-associated molecules are degraded by ALP, such as APP and BACE2 (Liu et al., 2013; Yang et al., 2013). Here, APP is linked to early-onset autosomal dominant Alzheimer disease.