Moreover, the dysregulation of TFEB and TFEB-mediated ALP contributes the pathogenesis of various neurodegenerative diseases including Alzheimer’s disease and Parkinson’s disease, while increasing TFEB expression or activation attenuates the pathogenesis of neurodegenerative diseases (Martini-Stoica et al., 2016; Cortes and La Spada, 2019). The gene discussed is TFEB; the disease is early-onset autosomal dominant Alzheimer disease.