GFI1 and myeloproliferative disorder: This is corroborated by studies in mice with reduced expression levels of GFI1 which results in a myeloproliferative disease that is not only fatal, but also resembles MDS and is a rather common to MPN in many aspects since it progressed to an overt leukemia when additional mutations were induced either by retroviral infection or chemical carcinogenesis (42).