GFI1 and acute myeloid leukemia: Further studies with 36N and 36S KI mice and other mouse models that carry a low-level expressing GFI1 allele (GFI1 expression knockdown or GFI1-KD animals) showed that either the presence of the GFI136N allele or reduced expression of the GFI1 gene accelerated both the initiation and progression of AML in mouse models in which myeloid leukemogenesis is driven by expression of an onco-fusion protein (17).