It has been observed that inhibition of LSD1 promotes differentiation of blast cells particularly in cases of AML with chromosomal translocations involving the gene encoding the histone methyl transferase KMT2A (MLL) such as the translocation between KMT2A-MLLT3 (MLL-AF9) or KMT2A-MLLT1 (MLL-ENL). This evidence concerns the gene MLLT3 and acute myeloid leukemia.