That study concluded that reduced Gfi1 levels represent a high risk for development of a myeloid leukemia, since the low Gfi1 levels lead to the accumulation of myeloid cells like in a full Gfi1-deficient animal, but a p53 mediated cell death is not activated in GFI1-KD cells as it is in Gfi1-deficient cells (42). This evidence concerns the gene GFI1 and myeloid leukemia.