To unveil the role of autophagy in lung cancer, the current study was designed and conducted based on our previous work, in which we found that let-7a-5p along with its 4 target genes, including BCL2-like protein 1 (BCL2L1), insulin-like growth factor 1 receptor (IGF1R), mitogen-activated protein kinase 8 (MAPK8), and FAS, were putatively associated with the autophagy of lung cancer cells (10), and BCL2L1 was confirmed to be negatively correlated with the survival of lung cancer patients. This evidence concerns the gene MAPK8 and lung cancer.