This possibility is supported by the fact that, without TKI treatment, the phosphorylation status of EGFR does not correlate with disease progression nor with prognosis of many cancers but the total EGFR protein level does (31, 32, 34, 38, 39, 80, 156–159) and further that the innate TKI resistant cancer cells cannot survive without EGFR (141–143, 215), and that disconnecting the EGFR's kinase activity from its downstream kinase cascades does not affect EGFR's oncogenic function (178). The gene discussed is EGFR; the disease is cancer.