Examples of cancers that exhibit increased EGFR expression along with disease progress and do not respond to TKIs include prostate cancer (133), ovarian cancer (157), pancreatic cancer (161), colorectal cancer (162), head and neck cancer (40), cervical cancer (163), and lung cancers expressing wild-type EGFR (128, 152, 164). This evidence concerns the gene EGFR and colorectal cancer.