EGFR and central nervous system cancer: This assumption has been negated by the observations of severe cell death upon down-regulating EGFR proteins in cancer cells of cancers innately resistant to EGFR kinase inhibitors, e.g., prostate cancer cells (141, 142), breast cancer, ovarian cancer cells, wild-type EGFR expressing lung cancer cells, wild-type EGFR expressing colon cancer cells (142–144), renal cancer (79), and glioma (145).