In patients with EGFR-mutant non-small cell lung cancer, patients receiving first-line EGFR-targeted therapies had improved OS, but were 1.35 times more likely to develop IMD compared with patients receiving other therapies (28), although other analyses suggest the same first-line EGFR-targeted therapies decrease the incidence of IMD (30, 31). This evidence concerns the gene EGFR and non-small cell lung carcinoma.