In addition, cultured CNS-1 cells overexpressing fibulin-3 exhibited significant positive regulation of the same metalloproteases at the mRNA and protein levels as well as a strong increase in metalloprotease activity, suggesting a direct regulatory effect of fibulin-3 on the expression of metalloproteases such as ADAMTS-5 and the proteolytic activity observed in glioma cells (88). The gene discussed is ADAMTS5; the disease is central nervous system cancer.