Consistent with this proinvasive role, CNS-1 glioma cell-induced tumors that overexpress fibulin-3 have significantly upregulated levels of mRNAs coding for several matricellular proteases, including MMP-2, MMP-9, and ADAMTS-5, all of which are involved in pericellular ECM degradation, glioma invasion, and intracranial tumor dispersion. Here, MMP2 is linked to central nervous system cancer.