However, the antitumor properties of fibulin-2 are the most well-known, for example, in nasopharyngeal carcinoma, where fibulin-2 acts as an antiangiogenic factor (67), or in breast cancer, where the reduction in fibulin-2 expression facilitates tumor progression, increasing cellular migratory and invasive properties (68). The gene discussed is FBLN2; the disease is neoplasm.