We simulated the pathways revealed by IPA and found that the EGFRvIII/PI3K/AKT/NF‐κB and G protein‐coupled receptor (GPCR)/PLA/PKC/NFAT pathways are the most responsible for TMZ resistance in EGFRvIII‐expressing GBM cells (Figure 2d; Table S4, Supporting Information). This evidence concerns the gene AKT1 and glioblastoma.