The inhibitory effects of bortezomib on cell growth are potentially because of downregulation of cytokines CXCL8 and CXCL1, which are regulated by NF‐κB and play an important role in promoting growth and metastasis of melanomas.17 However, CXCL8 and CXCL1 maybe are not the TMZ resistance genes, so the combined effect with TMZ might just be synergy of toxicity, not chemotherapy sensitization. Here, CXCL8 is linked to melanoma.