MGMT and neoplasm: This mismatch repair injury leads to replication‐associated DNA DSBs, often triggering cell death.12 The increase in the expression of O6‐methylated guanine‐DNA methylase (MGMT) has been shown to cause the resistance, which makes the tumor resistant to TMZ via repair of the O6 guanine adduct.13 In addition, growing evidence suggests that other proteins mediate tumor resistance to TMZ.