TNF and obesity due to melanocortin 4 receptor deficiency: Obesity increases the M1 macrophage infiltration in adipose tissue and promotes the secretion of pro‐inflammatory cytokines, such as TNF‐α and IL‐6, which lead to high risk of glucose intolerance and insulin resistance.315 Ma et al. synthesized a nanosized dextran–dexamethasone prodrug that was linked through an esterase‐sensitive ester bond.44 Dexamethasone is an anti‐inflammatory drug against M1 macrophage and has shown therapeutic effect in obesity and diabetic patients, while dextran can selectively bind to lectins and scavenger receptors on macrophages.