Calreticulin (CRT), a prophagocytic protein, can interact with low‐density lipoprotein receptor‐related protein 1 on APCs to trigger the CRT‐mediated phagocytosis and promote the activation of APCs.178, 179 Based on this theory, Yuan et al. developed a multivalent bi‐specific nanobioconjugate engager (mBiNE) for targeted immune‐mediated cancer treatment.140 A colloidal nanoparticle core was used as substrates to conjugate CRT and a targeting moiety for specific tumor cell recognition. Here, CALR is linked to cancer.