H2BC12L and neoplasm: In 2017, Min et al. presented a fascinating idea that nanoparticles could “capture” tumor‐derived protein antigens on the surface and transport them to APCs.139 They prepared PLGA NPs modified with varied chemical groups and found that these antigen‐capturing nanoparticles (AC‐NPs) successfully captured the tumor‐specific neoantigens as well as histone proteins and alarmins, indicating great potential to arouse strong antitumor immune response.