The tumor‐associated platelets protect the integrity of tumor blood vessels and hamper the accumulation of nanomedicines at tumor site.230, 231 To increase the perfusion and retention of drug‐loaded nanoparticles, Li et al. developed a dual drug delivery system containing a polymer core of polyetherimide (PEI)–(PLGA)2 that was loaded with antiplatelet Ab R300, chemotherapeutics DOX, and a shell layer with MMP‐2‐sensitive peptides.159 Depletion of platelets created openings in the tumor vessels for easier entrance of the drug‐loaded core nanoparticles. The gene discussed is MMP2; the disease is neoplasm.