IL4 and autoimmune disease: It has been widely used in the treatment of autoimmune disease and chronic skin inflammation.292, 316 In order to overcome the drawbacks of IL‐4, such as short half‐life and off‐target side effects, Raimondo and Mooney conjugated IL‐4 onto Au NPs to treat ischemic skeletal muscle injury.296 IL‐4‐Au NP injection induced more evident skew toward M2 macrophage and more significant decrease of M1 type in comparison with bolus IL‐4 in a mouse model, leading to functional muscle improvement and muscle regeneration.