CF is an autosomal recessive disorder that affects one in 3200 in the United States and is caused by bi-allelic pathogenic variants (either homozygous or compound heterozygous pathogenic alleles) in the cystic fibrosis transmembrane conductance regulator (CFTR) gene.11–13 The most common pathogenic CFTR allele, F508del, accounts for ~70% of known CF-causing alleles.14 The gene discussed is CFTR; the disease is cystic fibrosis.